Understanding Intention to Treat Analysis and Per Protocol Analysis
نویسندگان
چکیده
منابع مشابه
Analyzing symptom management trials: the value of both intention-to-treat and per-protocol approaches.
PURPOSE/OBJECTIVES Two analytical approaches are described for a randomized trial testing interventions for symptom management. DESIGN To compare an intention-to-treat with a perprotocol approach. SETTING Patients were accrued from six cancer centers. SAMPLE 94 men and 140 women with solid tumors were accrued. METHODS An intention-to-treat approach (as randomized) and per-protocol analy...
متن کاملScreening: the information individuals need to support their decision: per protocol analysis is better than intention-to-treat analysis at quantifying potential benefits and harms of screening
BACKGROUND Providing individuals with the information necessary to make informed decisions is now considered an ethical standard for health systems and general practitioners. DISCUSSION Results from intention-to-treat analysis have thus far been used to illustrate screening benefits and harms, but intention-to-treat analysis in most screening trials compares no intervention to invitation to s...
متن کاملIntention-to-treat analysis: implications for quantitative and qualitative research.
Intention-to-treat analysis is an important aspect of randomized controlled trials of health care interventions. The concept is now widely accepted in theory, but not always implemented in practice. Failure to analyse by intention-to-treat can give misleading and indeed life-threatening interpretations. In some studies, a case is put for estimating the effect that would have been observed if al...
متن کاملIntention-to-treat analysis in cluster randomized trials with noncompliance.
In cluster randomized trials (CRTs), individuals belonging to the same cluster are very likely to resemble one another, not only in terms of outcomes but also in terms of treatment compliance behavior. Although the impact of resemblance in outcomes is well acknowledged, little attention has been given to the possible impact of resemblance in compliance behavior. This study defines compliance in...
متن کاملDropout rates for intent-to-treat and per protocol analyses.
PURPOSE To describe dropout rates for the intent-to-treat and per protocol analyses from prospective clinical trials. METHODS Review of prospective multi-center parallel studies of 100 patients or more from 1996 onwards. RESULTS We identified 33 articles (70 treatment arms) that fit the criteria for this study. No statistical differences in dropout rates were observed among drug classes for...
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ژورنال
عنوان ژورنال: Journal of Tumor Medicine & Prevention
سال: 2018
ISSN: 2575-890X
DOI: 10.19080/jtmp.2018.03.555608